SNPs, transcriptional factor binding sites and disease
نویسندگان
چکیده
منابع مشابه
AKT3 rSNPs, Transcriptional Factor Binding Sites and Human Disease
Seven rSNPs (rs10157763, rs10927067, rs12031994, rs2125230, rs2345994, rs4132509 and rs4590646) in intron one of thev-akt murine thymoma viral oncogene homolog 3 (AKT3) gene have been significantly associated with either Chronic Mountain Sickness, Renal Cell Carcinoma risk or Aggressive Prostate Cancer. These rSNP alleles alter the DNA landscape for potential transcriptional factors (TFs) to at...
متن کاملATF3 rSNPs, transcriptional factor binding sites and human etiology
Three rSNPs (rs3125289, rs1877474 and rs11119982) in one intron of the activating transcription factor 3 (ATF3) gene have been significantly associated with the human etiology of hypospadias and may be associated with human disease. These rSNP alleles alter the DNA landscape for potential transcriptional factors (TFs) to attach resulting in changes in transcriptional factor binding sites (TFBS)...
متن کاملTBXA2R rSNPs, Transcriptional Factor Binding Sites and Asthma in Asians
Four regulatory single nucleotide polymorphisms (rSNPs) (rs2238631, rs2238632, rs2238633 and rs2238634) in intron one, two rSNPs (rs1131882 and rs4523) in exon 3 and one rSNP (rs5756) in the 3’UTR of the thromboxane A2 receptor (TBXA2R) gene have been associated with childhoodonset asthma in Asians. These rSNP alleles alter the DNA landscape for potential transcriptional factors (TFs) to attach...
متن کاملMining yeast transcriptional regulatory modules from factor DNA-binding sites and gene expression data.
UNLABELLED In eukaryotes, gene expression is controlled by various transcription factors that bind to the promoter regions. Transcription factors may act positively, negatively or not at all. Different combinations of them may also activate or repress gene expression, and form regulatory networks of transcription. Uncovering such regulatory networks is a central challenge in genomic biology. In...
متن کاملProteome-Wide Analysis of Disease-Associated SNPs That Show Allele-Specific Transcription Factor Binding
A causative role for single nucleotide polymorphisms (SNPs) in many genetic disorders has become evident through numerous genome-wide association studies. However, identification of these common causal variants and the molecular mechanisms underlying these associations remains a major challenge. Differential transcription factor binding at a SNP resulting in altered gene expression is one possi...
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ژورنال
عنوان ژورنال: Biomedical Genetics and Genomics
سال: 2017
ISSN: 2398-5399
DOI: 10.15761/bgg.1000132